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Central Cuba is an area rich in both historical and natural attractions. It is home to several wonderful colonial-era cities, as well as isolated and pristine beaches. Heading east from Matanzas into Cuba's central heartland, you first hit Villa Clara province, which is devoted largely to sugar cane, citrus, tobacco farming, and cattle ranching. The provincial capital, Santa Clara, a lively university town, is often called Che Guevara's City and features an impressive monument and plaza dedicated to the fallen revolutionary. To the north of Santa Clara lie the tiny and well-preserved colonial-era city of Remedios and the stunningly beautiful beach resort destination of la Cayería del Norte.

Abutting Villa Clara to the south is Cienfuegos province. The city of Cienfuegos is affectionately known as La Perla del Sur (The Southern Pearl). Cienfuegos is a busy port city with a pretty, colonial-era center and the country's second-longest seaside promenade, or Malecón. Cienfuegos is connected to Trinidad by a pretty coastal highway, and is definitely worth a visit on a loop trip around the region.

The province of Sancti Spíritus is the only one in Cuba to count two of the original seven villas (towns) in Cuba among its offerings. The preserved colonial city Trinidad, tucked in the southwest corner of the province, is the highlight of a visit to the central section of the country, or all of Cuba for that matter. The provincial capital, Sancti Spíritus, isn't a great deal larger than Trinidad, and though it is more ramshackle and rough around the edges, lacking Trinidad's remarkable collection of perfectly preserved architecture, it is still worth a visit to see a couple of its colonial highlights.